Alfred H. Schinkel : rechercher sur Z-Library

Le plus grand référentiel d'articles scientifiques au monde. 70,000,000+ d'articles gratuitement.

Don't use scam websites

Livres
Articles (120)
Les plus populaires
Liste
- Liste
- Tableau

1

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview

Schinkel, Alfred H., Jonker, Johan W.

Journal:

Advanced Drug Delivery Reviews

Année:

2012

Langue:

english

Fichier:

PDF, 596 KB

english, 2012

2

P-Glycoprotein, a gatekeeper in the blood–brain barrier

Alfred H Schinkel

Journal:

Advanced Drug Delivery Reviews

Année:

1999

Langue:

english

Fichier:

PDF, 481 KB

english, 1999

3

Normal Viability and Altered Pharmacokinetics in Mice Lacking mdr1-Type (Drug-Transporting) P-Glycoproteins

Alfred H. Schinkel, Ulrich Mayer, Els Wagenaar, Carla A. A. M. Mol, Liesbeth Van Deemter, Jaap J. M. Smit, Martin A. Van Der Valk, Arie C. Voordouw, Hergen Spits, Olaf Van Tellingen, J. Mark J. M. Zij

Journal:

Proceedings of the National Academy of Sciences

Année:

1997

Langue:

english

Fichier:

PDF, 1.55 MB

english, 1997

4

Drug disposition as determined by the interplay between drug-transporting and drug-metabolizing systems

Erin G. Schuetz, Alfred H. Schinkel

Journal:

Journal of Biochemical and Molecular Toxicology

Année:

1999

Langue:

english

Fichier:

PDF, 50 KB

english, 1999

5

Contribution of the murine mdr1a P-glycoprotein to hepatobiliary and intestinal elimination of cationic drugs as measured in mice with an mdr1a gene disruption

Johan W. Smit, Alfred H. Schinkel, Michael Müller, Betty Weert, Dirk K. F. Meijer

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 129 KB

english, 1998

6

Hepatocyte-specific expression of the human MDR3P-glycoprotein gene restores the biliary phosphatidylcholine excretion absent in Mdr2 (−/−) mice

Alexander J. Smith, J. Marleen de Vree, Roelof Ottenhoff, Ronald P. Elferink, Alfred H. Schinkel, Piet Borst

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 524 KB

english, 1998

7

MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid

Maarten T. Huisman, Aniska A. Chhatta, Olaf van Tellingen, Jos H. Beijnen, Alfred H. Schinkel

Journal:

International Journal of Cancer

Année:

2005

Langue:

english

Fichier:

PDF, 115 KB

english, 2005

8

Individual and combined roles of CYP3A, P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) in the pharmacokinetics of docetaxel

Robert A.B. van Waterschoot, Jurjen S. Lagas, Els Wagenaar, Hilde Rosing, Jos H. Beijnen, Alfred H. Schinkel

Journal:

International Journal of Cancer

Année:

2010

Langue:

english

Fichier:

PDF, 181 KB

english, 2010

9

Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration

Seng Chuan Tang, Jurjen S. Lagas, Nienke A.G. Lankheet, Birk Poller, Michel J. Hillebrand, Hilde Rosing, Jos H. Beijnen, Alfred H. Schinkel

Journal:

International Journal of Cancer

Année:

2012

Langue:

english

Fichier:

PDF, 886 KB

english, 2012

10

Binding properties of monoclonal antibodies recognizing external epitopes of the human MDR1 P-glycoprotein

Alfred H. Schinkel, Piet Borst, Jaap J. M. Smit, Els Wagenaar, Martijn Dollé, Robert J. Arceci, Frank Baas, Takashi Tsuruo, Eugene B. Mechetner, Igor B. Roninson

Journal:

International Journal of Cancer

Année:

1993

Langue:

english

Fichier:

PDF, 922 KB

english, 1993

11

An integrated pharmacokinetic model for the influence of CYP3A4 expression on the in vivo disposition of lopinavir and its modulation by ritonavir

Rob ter Heine, Robert A. B. Van Waterschoot, Ron J. Keizer, Jos H. Beijnen, Alfred H. Schinkel, Alwin D. R. Huitema

Journal:

Journal of Pharmaceutical Sciences

Année:

2011

Langue:

english

Fichier:

PDF, 267 KB

english, 2011

12

Liquid chromatography-tandem mass spectrometric assay for the light sensitive tyrosine kinase inhibitor axitinib in human plasma

Rolf W. Sparidans, Dilek Iusuf, Alfred H. Schinkel, Jan H.M. Schellens, Jos H. Beijnen

Journal:

Journal of Chromatography B

Année:

2009

Langue:

english

Fichier:

PDF, 589 KB

english, 2009

13

Liquid chromatography-tandem mass spectrometric assay for pravastatin and two isomeric metabolites in mouse plasma and tissue homogenates

Rolf W. Sparidans, Dilek Iusuf, Alfred H. Schinkel, Jan H.M. Schellens, Jos H. Beijnen

Journal:

Journal of Chromatography B

Année:

2010

Langue:

english

Fichier:

PDF, 669 KB

english, 2010

14

Inhibition of BCRP-mediated drug efflux by fumitremorgin-type indolyl diketopiperazines

Arnold van Loevezijn, John D Allen, Alfred H Schinkel, Gerrit-Jan Koomen

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2001

Langue:

english

Fichier:

PDF, 170 KB

english, 2001

15

Absence ofN-linked glycosylation does not affect plasma membrane localization of breast cancer resistance protein (BCRP/ABCG2)

Karin Mohrmann, Maria A. J. van Eijndhoven, Alfred H. Schinkel, Jan H. M. Schellens

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2005

Langue:

english

Fichier:

PDF, 323 KB

english, 2005

16

A sensitive assay for the quantitative analysis of vinorelbine in mouse and human EDTA plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry

Carola W.N. Damen, Hilde Rosing, Matthijs M. Tibben, Maria J. van Maanen, Jurjen S. Lagas, Alfred H. Schinkel, Jan H.M. Schellens, Jos H. Beijnen

Journal:

Journal of Chromatography B

Année:

2008

Langue:

english

Fichier:

PDF, 238 KB

english, 2008

17

Changes in dipole membrane potential at the mouse blood–brain barrier enhance the transport of 99mTechnetium Sestamibi more than inhibiting Abcb1, Abcc1, or Abcg2

Julie Cattelotte, Nicolas Tournier, Nathalie Rizzo-Padoin, Alfred H. Schinkel, Jean-Michel Scherrmann, Salvatore Cisternino

Journal:

Journal of Neurochemistry

Année:

2009

Langue:

english

Fichier:

PDF, 312 KB

english, 2009

18

Transport of Topoisomerase I Inhibitors by the Breast Cancer Resistance Protein: Potential Clinical Implications

JAN H.M. SCHELLENS, MARC MALIEPAARD, RIK J. SCHEPER, GEORGE L. SCHEFFER, JOHAN W. JONKER, JOHAN W. SMIT, JOS H. BEIJNEN, ALFRED H. SCHINKEL

Journal:

Annals of the New York Academy of Sciences

Année:

2000

Langue:

english

Fichier:

PDF, 202 KB

english, 2000

19

Hepatobiliary and intestinal clearance of amphiphilic cationic drugs in mice in which both mdr1a and mdr1b genes have been disrupted

Johan W Smit, Alfred H Schinkel, Betty Weert, Dirk K F Meijer

Journal:

British Journal of Pharmacology

Année:

1998

Langue:

english

Fichier:

PDF, 365 KB

english, 1998

20

BBB Transport and P-glycoprotein Functionality Using MDR1A (-/-) and Wild-Type Mice. Total Brain Versus Microdialysis Concentration Profiles of Rhodamine-123

Elizabeth C. M. de Lange, Gertjan de Bock, Alfred H. Schinkel, Albertus G. de Boer, Douwe D. Breimer

Journal:

Pharmaceutical Research

Année:

1998

Fichier:

PDF, 842 KB

1998

21

Role of acetylcholine and muscarinic receptors in serotonin-induced bronchoconstriction in the mouse

Wolfgang Kummer, Silke Wiegand, Sibel Akinci, Alfred H. Schinkel, Jürgen Wess, Hermann Koepsell, Rainer Viktor Haberberger, Katrin Susanne Lips

Journal:

Journal of Molecular Neuroscience

Année:

2006

Langue:

english

Fichier:

PDF, 65 KB

english, 2006

22

The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk

Jonker, Johan W, Merino, Gracia, Musters, Sandra, van Herwaarden, Antonius E, Bolscher, Ellen, Wagenaar, Els, Mesman, Elly, Dale, Trevor C, Schinkel, Alfred H

Journal:

Nature Medicine

Année:

2005

Langue:

english

Fichier:

PDF, 317 KB

english, 2005

23

Contribution of the ABC Transporters Bcrp1 and Mdr1a/1b to the Side Population Phenotype in Mammary Gland and Bone Marrow of Mice

Johan W. Jonker, Jamie Freeman, Ellen Bolscher, Sandra Musters, Azra J. Alvi, Ian Titley, Alfred H. Schinkel, Trevor C. Dale

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 296 KB

english, 2005

24

The physiological function of drug-transporting P-glycoproteins

Alfred H. Schinkel

Journal:

Seminars in Cancer Biology

Année:

1997

Langue:

english

Fichier:

PDF, 206 KB

english, 1997

25

Characterization of the promoter region of the human MDR3 P-glycoprotein gene

Jaap J.M. Smit, Carla A.A.M. Mol, Liesbeth van Deemter, Els Wagenaar, Alfred H. Schinkel, Piet Borst

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Année:

1995

Langue:

english

Fichier:

PDF, 1.24 MB

english, 1995

26

Book review

Alfred H. Schinkel, Henk F. Tabak

Journal:

Trends in Genetics

Année:

1989

Langue:

english

Fichier:

PDF, 599 KB

english, 1989

27

Physiological and pharmacological roles of ABCG2 (BCRP): Recent findings in Abcg2 knockout mice

Maria L.H. Vlaming, Jurjen S. Lagas, Alfred H. Schinkel

Journal:

Advanced Drug Delivery Reviews

Année:

2009

Langue:

english

Fichier:

PDF, 856 KB

english, 2009

28

PXR-mediated induction of human CYP3A4 and mouse Cyp3a11 by the glucocorticoid budesonide

Christian Zimmermann, Robert A.B. van Waterschoot, Stefan Harmsen, Angelika Maier, Heike Gutmann, Alfred H. Schinkel

Journal:

European Journal of Pharmaceutical Sciences

Année:

2009

Langue:

english

Fichier:

PDF, 382 KB

english, 2009

29

Liquid chromatography–tandem mass spectrometric assay for the VEGFR inhibitor cediranib and its primary human metabolite cediranib-N+-glucuronide in plasma

Rolf W. Sparidans, Selvi Durmus, Ning Xu, Alfred H. Schinkel, Jan H.M. Schellens, Jos H. Beijnen

Journal:

Journal of Chromatography B

Année:

2012

Langue:

english

Fichier:

PDF, 275 KB

english, 2012

30

Liquid chromatography–tandem mass spectrometric assay for the JAK2 inhibitor CYT387 in plasma

Rolf W. Sparidans, Selvi Durmus, Ning Xu, Alfred H. Schinkel, Jan H.M. Schellens, Jos H. Beijnen

Journal:

Journal of Chromatography B

Année:

2012

Langue:

english

Fichier:

PDF, 269 KB

english, 2012

31

Genetic dissection of the function of mammalian P-glycoproteins

Piet Borst, Alfred H. Schinkel

Journal:

Trends in Genetics

Année:

1997

Langue:

english

Fichier:

PDF, 762 KB

english, 1997

32

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview

Alfred H Schinkel, Johan W Jonker

Journal:

Advanced Drug Delivery Reviews

Année:

2003

Langue:

english

Fichier:

PDF, 459 KB

english, 2003

33

Modulation of oral bioavailability of anticancer drugs: from mouse to man

Jan H.M Schellens, Mirte M Malingré, C.Marielle F Kruijtzer, H.A Bardelmeijer, Olaf van Tellingen, Alfred H Schinkel, Jos H Beijnen

Journal:

European Journal of Pharmaceutical Sciences

Année:

2000

Langue:

english

Fichier:

PDF, 256 KB

english, 2000

34

Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdrla P-glycoprotein

Ulrich Mayer, Els Wagenaar, Jos H. Beijnen, Johan W. Smit, Dirk K.F. Meijer, Judith van Asperen, Piet Borst, Alfred H. Schinkel

Journal:

British Journal of Pharmacology

Année:

1996

Langue:

english

Fichier:

PDF, 1.33 MB

english, 1996

35

The human MDR3 P-glycoprotein promotes translocation of phosphatidylcholine through the plasma membrane of fibroblasts from transgenic mice

Alexander J. Smith, Johanna L.P.M. Timmermans-Hereijgers, Ben Roelofsen, Karel W.A. Wirtz, Wim J. van Blitterswijk, Jaap J.M. Smit, Alfred H. Schinkel, Piet Borst

Journal:

Année:

1994

Langue:

english

Fichier:

PDF, 522 KB

english, 1994

36

A sensitive combined assay for the quantification of paclitaxel, docetaxel and ritonavir in human plasma using liquid chromatography coupled with tandem mass spectrometry

Jeroen J.M.A. Hendrikx, Michel J.X. Hillebrand, Bas Thijssen, Hilde Rosing, Alfred H. Schinkel, Jan H.M. Schellens, Jos H. Beijnen

Journal:

Journal of Chromatography B

Année:

2011

Langue:

english

Fichier:

PDF, 541 KB

english, 2011

37

Liquid chromatography–tandem mass spectrometric assay for the mutated BRAF inhibitor vemurafenib in human and mouse plasma

Rolf W. Sparidans, Selvi Durmus, Alfred H. Schinkel, Jan H.M. Schellens, Jos H. Beijnen

Journal:

Journal of Chromatography B

Année:

2012

Langue:

english

Fichier:

PDF, 253 KB

english, 2012

38

The function of breast cancer resistance protein in epithelial barriers, stem cells and milk secretion of drugs and xenotoxins

Antonius E. van Herwaarden, Alfred H. Schinkel

Journal:

Trends in Pharmacological Sciences

Année:

2006

Langue:

english

Fichier:

PDF, 217 KB

english, 2006

39

How important is intestinal cytochrome P450 3A metabolism?

Antonius E. van Herwaarden, Robert A.B. van Waterschoot, Alfred H. Schinkel

Journal:

Trends in Pharmacological Sciences

Année:

2009

Langue:

english

Fichier:

PDF, 240 KB

english, 2009

40

Functions of OATP1A and 1B transporters in vivo: insights from mouse models

Dilek Iusuf, Evita van de Steeg, Alfred H. Schinkel

Journal:

Trends in Pharmacological Sciences

Année:

2012

Langue:

english

Fichier:

PDF, 771 KB

english, 2012

41

MDR1 P-Glycoprotein Is a Lipid Translocase of Broad Specificity, While MDR3 P-Glycoprotein Specifically Translocates Phosphatidylcholine

Ardy van Helvoort, Alexander J Smith, Hein Sprong, Ingo Fritzsche, Alfred H Schinkel, Piet Borst, Gerrit van Meer

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 1.25 MB

english, 1996

42

Organic Cation Transporter 2 Mediates Cisplatin-Induced Oto- and Nephrotoxicity and Is a Target for Protective Interventions

Giuliano Ciarimboli, Dirk Deuster, Arne Knief, Michael Sperling, Michael Holtkamp, Bayram Edemir, Hermann Pavenstädt, Claudia Lanvers-Kaminsky, Antoinette am Zehnhoff-Dinnesen, Alfred H. Schinkel, Her

Journal:

The American Journal of Pathology

Année:

2010

Langue:

english

Fichier:

PDF, 1018 KB

english, 2010

43

Oral Availability and Brain Penetration of the B-RAF V600E Inhibitor Vemurafenib Can Be Enhanced by the P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) Inhibitor Elacridar

Durmus, Selvi, Sparidans, Rolf W., Wagenaar, Els, Beijnen, Jos H., Schinkel, Alfred H.

Journal:

Molecular Pharmaceutics

Année:

2012

Langue:

english

Fichier:

PDF, 1.06 MB

english, 2012

44

Regulation of protein secretion into bile: Studies in mice with a disrupted mdr2 p-glycoprotein gene

Albert K. Groen, Michel J.A. van Wijland, Wilma M. Frederiks, Jaap J.M. Smit, Alfred H. Schinkel, Ronald P.J. Oude Elferink

Journal:

Gastroenterology

Année:

1995

Langue:

english

Fichier:

PDF, 3.88 MB

english, 1995

45

Naturally occurring leukemia viruses in H-2 congenic C57BL mice III. Characterization of C-type viruses isolated from lymphomas induced by milk transmission of B-ecotropic virus

Maarten Zijlstra, Ruud E.Y. de Goede, Harrie J. Schoenmakers, Alfred H. Schinkel, Wim G. Hesselink, John L. Portis, Cornelis J.M. Melief

Journal:

Année:

1983

Langue:

english

Fichier:

PDF, 5.44 MB

english, 1983

46

Liquid chromatography–tandem mass spectrometric assay for the ALK inhibitor crizotinib in mouse plasma

Rolf W. Sparidans, Seng Chuan Tang, Luan N. Nguyen, Alfred H. Schinkel, Jan H.M. Schellens, Jos H. Beijnen

Journal:

Journal of Chromatography B

Année:

2012

Langue:

english

Fichier:

PDF, 429 KB

english, 2012

47

Activation of the genes for variant surface glycoproteins 117 and 118 in Trypanosoma brucei

Paul A.M. Michels, Alvin Y.C. Liu, André Bernards, Paul Sloof, Mara M.W. Van Der Bijl, Alfred H. Schinkel, Hilly H. Menke, Piet Borst, Gerrit H. Veeneman, Marijke C. Tromp, Jacques H. Van Boom, P. Cha

Journal:

Journal of Molecular Biology

Année:

1983

Langue:

english

Fichier:

PDF, 2.65 MB

english, 1983

48

Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse

Wolfgang Kummer, Silke Wiegand, Sibel Akinci, Ignatz Wessler, Alfred H Schinkel, Jürgen Wess, Hermann Koepsell, Rainer V Haberberger, Katrin S Lips

Journal:

Respiratory Research

Année:

2006

Langue:

english

Fichier:

PDF, 3.20 MB

english, 2006

49

Liquid chromatography–tandem mass spectrometric assay for the mutated BRAF inhibitor dabrafenib in mouse plasma

Sparidans, Rolf W., Durmus, Selvi, Schinkel, Alfred H., Schellens, Jan H.M., Beijnen, Jos H.

Journal:

Journal of Chromatography B

Année:

2013

Langue:

english

Fichier:

PDF, 274 KB

english, 2013

50

Genetically modified mouse models for oral drug absorption and disposition

Tang, Seng Chuan, Hendrikx, Jeroen JMA, Beijnen, Jos H, Schinkel, Alfred H

Journal:

Current Opinion in Pharmacology

Année:

2013

Langue:

english

Fichier:

PDF, 543 KB

english, 2013